Table 2. Logistic regression univariate and multivariate analysis of factors associated with treatment success in patients starting drug resistant-TB treatment (DR-TB) from 2008 to 2012.
Factor | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
Odds ratio (95% CI) | p-value | Adjusted odds ratio (95% CI) | p-value | |
HIV status | ||||
Uninfected | 1.0 (reference) | 1.0 (reference) | ||
Infected | 1.1 (0.80–1.5) | 0.59 | 0.78 (0.54–1.1) | 0.21 |
Gender | ||||
Male | 1.0 (reference) | 1.0 (reference) | ||
Female | 1.4 (1.0–1.8) | 0.035 | 1.6 (1.1–2.2) | 0.005 |
Age category (years) | ||||
<=15 | 3.0 (1.1–8.8) | 0.039 | 2.1 (0.71–6.4) | 0.17 |
16–24 | 0.62 (0.40–0.96) | 0.032 | 0.57 (0.35–0.93) | 0.024 |
25–34 | 1.0 (reference) | 1.0 (reference) | ||
35–44 | 1.3 (0.94–1.9) | 0.10 | 1.5 (1.1–2.2) | 0.024 |
>44 | 1.2 (0.74–1.8) | 0.54 | 1.4 (0.86–2.2) | 0.17 |
Disease site | ||||
PTB | 1.0 (reference) | 1.0 (reference) | ||
EPTB | 2.7 (1.5–5.0) | 0.001 | 2.6 (1.4–5.1) | 0.004 |
Both | 1.9 (0.72–4.9) | 0.19 | 2.0 (0.73–5.3) | 0.18 |
Baseline smear status (if PTB) | ||||
Negative | 1.0 (reference) | 1.0 (reference) | ||
Positive | 0.77 (0.57–1.1) | 0.10 | 0.86 (0.63–1.2) | 0.36 |
Unknown | 1.4 (0.65–3.1) | 0.39 | 1.3 (0.61–3.0) | 0.46 |
EPTB- no smear | 2.4 (1.3–4.4) | 0.007 | NA | NA |
DR-TB classification | ||||
Rifampicin-mono TBa | 1.0 (reference) | 1.0 (reference) | ||
MDR-TBb | 0.95 (0.67–1.3) | 0.76 | 0.99 (0.68–1.4) | 0.95 |
MDR-TB with second-line drug resistance | 0.55 (0.33–0.90) | 0.018 | 0.54 (0.32–0.91) | 0.021 |
Previous TB treatment | ||||
No previous TB treatment | 1.0 (reference) | NA | 1.0 (reference) | NA |
Previous first-line TB treatment | 0.68 (0.50–0.92) | 0.014 | 0.66 (0.47–0.91) | 0.012 |
DR-TB: drug resistant TB; EPTB: extra-pulmonary TB; MDR-TB: multi-drug resistant TB; NA: not applicable; PTB: pulmonary TB.
Includes unconfirmed GeneXpert rifampicin-resistant TB.
MDR-TB with no confirmed second-line resistance.