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. Author manuscript; available in PMC: 2019 Jun 4.
Published in final edited form as: Trans R Soc Trop Med Hyg. 2015 May 15;109(7):425–432. doi: 10.1093/trstmh/trv037

Table 2. Logistic regression univariate and multivariate analysis of factors associated with treatment success in patients starting drug resistant-TB treatment (DR-TB) from 2008 to 2012.

Factor Univariate analysis Multivariate analysis


Odds ratio (95% CI) p-value Adjusted odds ratio (95% CI) p-value
HIV status
    Uninfected   1.0 (reference)   1.0 (reference)
    Infected   1.1 (0.80–1.5) 0.59 0.78 (0.54–1.1) 0.21
Gender
    Male   1.0 (reference)   1.0 (reference)
    Female   1.4 (1.0–1.8) 0.035   1.6 (1.1–2.2) 0.005
Age category (years)
    <=15   3.0 (1.1–8.8) 0.039   2.1 (0.71–6.4) 0.17
    16–24 0.62 (0.40–0.96) 0.032 0.57 (0.35–0.93) 0.024
    25–34   1.0 (reference)   1.0 (reference)
    35–44   1.3 (0.94–1.9) 0.10   1.5 (1.1–2.2) 0.024
    >44   1.2 (0.74–1.8) 0.54   1.4 (0.86–2.2) 0.17
Disease site
    PTB   1.0 (reference)   1.0 (reference)
    EPTB   2.7 (1.5–5.0) 0.001   2.6 (1.4–5.1) 0.004
    Both   1.9 (0.72–4.9) 0.19   2.0 (0.73–5.3) 0.18
Baseline smear status (if PTB)
    Negative   1.0 (reference)   1.0 (reference)
    Positive 0.77 (0.57–1.1) 0.10 0.86 (0.63–1.2) 0.36
    Unknown   1.4 (0.65–3.1) 0.39   1.3 (0.61–3.0) 0.46
    EPTB- no smear   2.4 (1.3–4.4) 0.007 NA NA
DR-TB classification
    Rifampicin-mono TBa   1.0 (reference)   1.0 (reference)
    MDR-TBb 0.95 (0.67–1.3) 0.76 0.99 (0.68–1.4) 0.95
    MDR-TB with second-line drug resistance 0.55 (0.33–0.90) 0.018 0.54 (0.32–0.91) 0.021
Previous TB treatment
    No previous TB treatment   1.0 (reference) NA   1.0 (reference) NA
    Previous first-line TB treatment 0.68 (0.50–0.92) 0.014 0.66 (0.47–0.91) 0.012

DR-TB: drug resistant TB; EPTB: extra-pulmonary TB; MDR-TB: multi-drug resistant TB; NA: not applicable; PTB: pulmonary TB.

a

Includes unconfirmed GeneXpert rifampicin-resistant TB.

b

MDR-TB with no confirmed second-line resistance.