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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cancer Res. 2019 Apr 5;79(11):2962–2977. doi: 10.1158/0008-5472.CAN-18-3151

Figure 7. MMP inhibitor treatment attenuated collective migration in a time-independent manner.

Figure 7.

MMP inhibitor treatment (20μM of GM6001) on day 1–6 and day 4–6 decreased (A) sE-CAD levels (ELISA), (B) sE-CAD and FN expression (western blot) in 600/CM, (C) downregulated MMP9 mRNA expression, (D) inhibited migration significantly, (E) downregulated VIM and FN mRNA expression, and (F) pERK microtumors compared to untreated controls. Data is presented as means ± SEM from 3 independent experiments. **p<0.01, ***p<0.001, ****p<0.0001; w.r.t. untreated control; One-way ANOVA followed by Tukey’s test.