Table 2.
Top 5 pathways enriched per metabolite based on gene expression analyses.
| Metabolite | Biological Pathways | P-value | Genes |
|---|---|---|---|
| Pyroglutamate | Iron homeostasis signaling pathway | 1.3E-04 | HBZ, FTL, HSCB, CIAO1, BMP6, CUL1, SLC48A1 |
| Ceramide Degradation | 1.5E-03 | ACER3, NAAA | |
| Sphingosine and Sphingosine-1-phosphate Metabolism | 2.6E-03 | ACER3, NAAA | |
| Biotin-carboxyl Carrier Protein Assembly | 2.6E-02 | ACACB | |
| Glutathione Biosynthesis | 2.6E-02 | GCLM | |
| Laurate | Ephrin B Signaling | 7.2E-04 | HNRNPK, GNB1, PXN, RAC2, EPHB1 |
| Inflammasome pathway | 9.1E-04 | MYD88, NLRP1, PYCARD | |
| Germ Cell-Sertoli Cell Junction Signaling | 1.3E-03 | IQGAP1, PAK2, PIK3CD, RHOB, PXN, TUBA4A, RAC2 | |
| Melanocyte Development and Pigmentation Signaling | 2.6E-03 | PIK3CD, PLCG1, RPS6KA4, RPS6KC1, PRKAR1A | |
| SAPK/JNK Signaling | 2.7E-03 | PIK3CD, MAP4K2, HNRNPK, GNB1, RAC2 | |
| Phosphatidylcholine PC ae C42:5 | Asparagine Biosynthesis I | 1.1E-02 | ASNS |
| Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency | 1.4E-02 | FAM208A, IGF2BP1, NR2F6 | |
| Dolichol and Dolichyl Phosphate Biosynthesis | 2.2E-02 | DOLK | |
| 1,25-dihydroxyvitamin D3 Biosynthesis | 3.3E-02 | CYP2R1 | |
| S-adenosyl-L-methionine Biosynthesis | 3.3E-02 | MAT2A | |
| Phosphatidylcholine PC ae C40:5 | Oxidative Phosphorylation | 2.8E-05 | NDUFB6, COX17, NDUFA7, NDUFB7, ATP5PF, COX5B, VPS9D1 |
| Mitochondrial Dysfunction | 1.1E-04 | CYB5R3, NDUFB6, COX17, NDUFA7, NDUFB7, ATP5PF, COX5B, VPS9D1 | |
| Sirtuin Signaling Pathway | 1.3E-03 | NDUFB6, PARP1, NDUFA7, NDUFB7, ATP5PF, GADD45A, POLR1C, SLC2A1, ATG16L2 | |
| Death Receptor Signaling | 1.9E-03 | PARP12, PARP1, DFFA, PARP14, BIRC3 | |
| Calcium-induced T Lymphocyte Apoptosis | 1.9E-03 | HLA-DQB1, EP300, CD4, PPP3CC | |
| Tetradecenoyl-L-carnitine (C14:1) | Antigen Presentation Pathway | 4.3E-08 | HLA-DPB1, HLA-DOA, HLA-DMA, HLA-DPA1, HLA-DMB, HLA-DRA, CIITA |
| Allograft Rejection Signaling | 1.5E-06 | HLA-DPB1, HLA-DOA, HLA-DMA, HLA-DPA1, HLA-DMB, HLA-DRA | |
| OX40 Signaling Pathway | 6.6E-06 | HLA-DPB1, HLA-DOA, HLA-DMA, HLA-DPA1, HLA-DMB, HLA-DRA | |
| Cdc42 Signaling | 1.9E-05 | HLA-DPB1, HLA-DOA, HLA-DMA, HLA-DPA1, HLA-DMB, HLA-DRA, ARPC1A, VAV2 | |
| B Cell Development | 7.8E-05 | HLA-DOA, HLA-DMA, HLA-DMB, HLA-DRA | |
| N-Methylmaleimide | Oxidative Phosphorylation | 6.0E-06 | ATP5S, NDUFA4, COX7B, NDUFA9, NDUFA6, ATP5F1C, UQCRB, NDUFAB1 |
| Sirtuin Signaling Pathway | 7.6E-06 | NFKB1, GOT2, CLOCK, SP1, NDUFAB1, RELA, NDUFA4, PARP1, ATG3, NDUFA9, NDUFA6, ATP5F1C, GTF3C2 | |
| Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate) | 2.0E-05 | IDI1, HMGCR, FNTB, ACAT1 | |
| Mitochondrial Dysfunction | 3.6E-05 | ATP5S, NDUFA4, COX7B, NDUFA9, NDUFA6, CASP3, ATP5F1C, UQCRB, NDUFAB1 | |
| Mevalonate Pathway I | 2.4E-04 | IDI1, HMGCR, ACAT1 |