Table 3.
Univariate Analysis for patient with the lung dose data
| Variable | Level | TRM | RFS | OS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Ratio | 95%CI for HR | P-value | Hazard Ratio | 95%CI for HR | P-value | Hazard Ratio | 95%CI for HR | P-value | |||||
| Lung dose (Continuous) | 1.001 | 0.999 | 1.003 | 0.4635 | 1.001 | 1.000 | 1.002 | 0.1182 | 1.001 | 1.000 | 1.002 | 0.1026 | |
| Lung dose (dichotomized) | < 800 (Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| >=800 | 1.781 | 0.721 | 4.398 | 0.2111 | 1.758 | 1.030 | 3.000 | 0.0384 | 1.855 | 1.039 | 3.312 | 0.0367 | |
| Dose rate (Continuous) | 0.963 | 0.858 | 1.081 | 0.5261 | 1.018 | 0.965 | 1.073 | 0.5227 | 1.008 | 0.947 | 1.073 | 0.7938 | |
| FieldName | AP (Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| RIAT | 1.037 | 0.435 | 2.475 | 0.9341 | 1.337 | 0.807 | 2.214 | 0.2601 | 1.342 | 0.776 | 2.320 | 0.2919 | |
| Position | Standing (Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| Decubitus | 1.540 | 0.446 | 5.325 | 0.4948 | 1.130 | 0.430 | 2.971 | 0.8037 | 1.242 | 0.462 | 3.336 | 0.6671 | |
| Seated | 1.039 | 0.300 | 3.600 | 0.9524 | 2.178 | 1.011 | 4.693 | 0.0467 | 1.669 | 0.722 | 3.859 | 0.2310 | |
| Supine | 0.848 | 0.268 | 2.683 | 0.7796 | 1.797 | 0.865 | 3.733 | 0.1161 | 1.612 | 0.745 | 3.488 | 0.2251 | |
| Risk groups | IR_CR2(Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| HR_CR2 | 5.966 | 0.784 | 45.411 | 0.0846 | 5.498 | 1.694 | 17.841 | 0.0045 | 5.066 | 1.557 | 16.484 | 0.0070 | |
| VHR_CR1 | 3.044 | 0.365 | 25.362 | 0.3033 | 3.655 | 1.089 | 12.263 | 0.0359 | 2.219 | 0.638 | 7.725 | 0.2103 | |
| Donor | Other (Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| Matched | 0.221 | 0.081 | 0.601 | 0.0031 | 0.456 | 0.274 | 0.758 | 0.0025 | 0.440 | 0.253 | 0.764 | 0.0035 | |
| MRD levels | MRD < 0.1% (Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| MRD >= 0.1% | 0.981 | 0.222 | 4.332 | 0.9795 | 2.818 | 1.417 | 5.605 | 0.0031 | 2.495 | 1.178 | 5.284 | 0.0170 | |
| Treatment | TacroMTX (Reference) | 1.000 | 1.000 | 1.000 | |||||||||
| TacroMTX_Sirolimus | 1.405 | 0.606 | 3.259 | 0.4277 | 1.286 | 0.781 | 2.117 | 0.3228 | 1.223 | 0.713 | 2.096 | 0.4653 | |
Abbreviations: TRM-treatment related mortality, PFS-Progression-free survival, OS-overall survival; HR-high risk; IR-intermediate risk; CR-complete remission; VHR-very high risk; aGVHD-acute graft versus host disease; VOD-veno-occlusive disease; MRD-minimal residual disease; TRM-transplant-related mortality, TBI-total body irradiation;
*
Logrank test