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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Mol Cancer Res. 2019 Mar 12;17(6):1391–1402. doi: 10.1158/1541-7786.MCR-18-0763

Figure 2. Ectopic E-cadherin expression in sarcoma cells does not alter EMT.

Figure 2.

A. Ectopic expression of E-cadherin in 143B human osteosarcoma cells has no influence on mesenchymal markers (Snail, Slug, Twist, Zeb1, Vimentin). B. E-cadherin expression has no effect on migration of 143B cells. C. Images in B were collected every two hours and quantified using the IncuCyte Zoom system. D. E-cadherin expression does not change invasion in 143B cells. E. Using mRNA expression of CDH1 (E-cadherin), empirical probably density functions of EMT scores for CDH1-high (red) and CDH1-low (blue) TCGA sarcoma sample were constructed by interpolation of the EMT score histogram (E<0.5, 0.5≤E/M≤1.5, M>1.5). EMT score distribution showed no significant difference when separated for E-cadherinhigh vs. E-cadherinlow expression from analysis of publicly-available sarcoma data sets.