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A-B. TBX2 mRNA is downregulated in E-cadherin-expressing A. 143B cells and B. U2OS cells. C. CREB knockdown with two independent siRNAs had no effect on TBX2 mRNA. D-F. Conversely, TBX2 knockdown, verified in D. led to a significant reduction in CREB mRNA (E) and protein level (F).
