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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Mol Cancer Res. 2019 Mar 12;17(6):1391–1402. doi: 10.1158/1541-7786.MCR-18-0763

Figure 7. E-cadherin inhibits spheroid formation by increased cell-cell adhesion.

Figure 7.

A. E-cadherin causes tighter clustering of cells during spheroid formation. B. A mechanical model illustrates the relationship between particle distance to adhesion. C. A mechanical model predicts E-cadherin drives down spheroid size through an increase in cell-cell adhesion. D-E. As predicted in the model, ectopic E-cadherin expression increases cell-cell adhesion in 143B (D) and U2OS (E) cells.