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. Author manuscript; available in PMC: 2020 Jun 5.
Published in final edited form as: ChemMedChem. 2019 Apr 10;14(11):1096–1107. doi: 10.1002/cmdc.201900114

Figure 7.

Figure 7

Hypothesis: Unlike scaffolding HDACs, catalytically active HDACs are able to bind substrates, small molecule HDACi, and HDAC PRPs. PTMs and HDAC protein complex components define whether the role of HDAC isoform is catalytic or scaffolding in cell-type, cell-cycle, and subcellular location manner.