Table 1:
Baseline participant characteristics by relative telomere length quartile at blood draw in 1989/1990
| 1st Quartile (n=2200) | 2nd Quartile (n=2200) | 3rd Quartile (n=2201) | 4th Quartile (n=2200) | |
|---|---|---|---|---|
| Age*†, (SD) | 59.1 (6.2) | 58.6 (6.5) | 58.0 (6.4) | 57.5 (6.6) |
| MHI-5 score‡ (SD) | 78.0 (13.8) | 78.9 (13.4) | 77.7 (14.4) | 78.4 (13.4) |
| Case status§, % | 35 | 35 | 34 | 35 |
| Pack-years of smoking, (SD) | 12.5 (18.1) | 12.1 (17.7) | 12.0 (17.9) | 11.8 (18.0) |
| Body mass index, (SD) | 25.2 (4.8) | 25.4 (4.8) | 25.2 (4.7) | 25.2 (4.6) |
| Antidepressant use, % | 5 | 4 | 4 | 4 |
| Alcohol intake, gm/wk (SD) | 5.6 (9.7) | 5.5 (9.6) | 5.6 (9.9) | 5.2 (8.8) |
| Physical activity, MET hrs/wk (SD) | 16.9 (23.6) | 16.9 (21.8) | 17.1 (25.8) | 16.1 (17.7) |
| Education: BA, % | 20 | 21 | 19 | 22 |
| Education: MA or DR, % | 11 | 10 | 10 | 10 |
| Pre-menopausal, % | 14 | 14 | 14 | 13 |
| Post-menopausal & currently on HRT, % | 35 | 35 | 36 | 35 |
| Paternal age-at-birth, (SD) | 31.0 (6.9) | 31.7 (7.2) | 31.6 (7.1) | 31.7 (6.9) |
| Hypertension, % | 29 | 30 | 29 | 30 |
| High cholesterol, % | 42 | 43 | 44 | 44 |
| CVD (MI, stroke, CABG) , % | 7 | 5 | 6 | 5 |
| Diabetes, % | 4 | 5 | 4 | 4 |
| Respiratory disease , % | 9 | 9 | 8 | 7 |
| Charlson Index¶, (SD) | 0.2 (0.6) | 0.2 (0.6) | 0.2 (0.5) | 0.2 (0.5) |
Values are means (SD) or percentages and are standardized to the age distribution of the study population.
†
Value is not age- adjusted
‡
Mental Health Inventory-5
§
Classified as a “case” in the nested case-control studies of various diseases used to form analytic sample
¶
All comorbidities are from self-reports of diagnosis by a healthcare professional Charlson Comorbidity Index(Charlson et al., 1987)