Table 2a:

Odds of being in each trajectory group, compared to the odds of being in the minimal symptoms group (reference category), per standard deviation increase in relative telomere length (cases and controls, n=8801).^†

Depressive Symptom Trajectory Group	Age-only adjusted Odds Ratio	95% CI	P-Value	Adjusted Odds Ratio*	95% CI	P-Value
Minimal Symptoms (n=5456)	Ref	Ref	Ref	Ref	Ref	Ref
Improving Symptoms (1672)	1.10	(0.91, 1.34)	0.32	1.10	(0.90,1.34)	0.36
Worsening Symptoms (n=1232)	0.69	(0.55, 0.86)	0.001	0.78	(0.62, 0.97)	0.02
Persistent Symptoms (n=441)	0.95	(0.71, 1.27)	0.72	1.02	(0.76, 1.37)	0.89

^†Adjusted for case/control status, pack years of smoking, BMI, antidepressant use, alcohol consumption, physical activity (MET hours/week), menopausal & hormone replacement therapy status, Charlson Index score, and paternal age at birth. Cases and controls were from nested case-control studies of various diseases in the Nurses’ Health Study blood cohort.