Table 2:
Tumor mutational burden in 9,407 patients with squamous cell carcinoma
| Median TMB (IQR) | P value | Low TMB (<6 mutations/mb) | Intermediate TMB (6–19 mutations/mb) | High TMB (≥20 <50) mutations/mb) | Very High TMB (≥50 mutations/mb) | TMB <12 mutations/mb | TMB ≥12 mutations/mb | P value | Odds Ratio (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Tumors UCSD cohort (N = 2651) | Percent of patients | Percent of patients | ||||||||
| Squamous tumors (N=180)** | 6 (13) | <0.0001 | 37.2 | 41.1 | 21.7 | 10.0 | 66.1 | 33.9 | <0.0001 | 4.7 (3.3–6.7) |
| Non-squamous tumors (N=2471) | 2 (5) | 74.8 | 19.5 | 5.7 | 2.5 | 90.2 | 9.8 | <0.0001 | 0.2 (0.1–0.3) | |
| Squamous tumors (FM cohort) (N = 9407)** | ||||||||||
| Cutaneous (N=426) | 40 (68) | <0.0001 | 22.3 | 16.0 | 61.7 | 41.3 | 33.1 | 66.9 | <0.0001 | 5.8 (4.7–7.2) |
| Non-cutaneous (N=8981) | 6 (9) | 42.2 | 47.6 | 10.2 | 3.0 | 74.2 | 25.8 | <0.0001 | 0.2 (0.1–0.2) | |
| Squamous tumor subsets | ||||||||||
| Cutaneous (N=426) | 40 (68) | <0.0001 | 22.3 | 16.0 | 61.7 | 41.3 | 33.1 | 66.9 | <0.0001 | 5.8 (4.7–7.3) |
| Lung (N=4096) | 8 (8) | 28.1 | 61.9 | 10.0 | 1.6 | 66.3 | 33.7 | <0.0001 | 1.8 (1.7–2.0) | |
| Head and neck (N=1938) | 4 (6) | 57.8 | 31.3 | 10.9 | 5.4 | 82.0 | 18.0 | <0.0001 | 0.5 (0.4–0.6) | |
| Esophageal (N=423) | 5 (4) | 57.2 | 40.7 | 2.1 | 0.5 | 89.8 | 10.2 | <0.0001 | 0.3 (0.2–0.4) | |
| Anal (N=390) | 5 (5) | 58.2 | 38.0 | 3.8 | 0.8 | 89.0 | 11.0 | <0.0001 | 0.3 (0.2–0.4) | |
| Cervical (N=541) | 5 (5) | 54.9 | 38.6 | 6.5 | 0.4 | 83.9 | 16.1 | <0.0001 | 0.5 (0.4–0.6) | |
| Urothelial (N=74) | 6 (6) | 43.2 | 44.6 | 12.2 | 0.0 | 81.1 | 18.9 | 0.09 | 0.6 (0.3–1.1) | |
*
P values of median TMB were determined using Mann-Whitney U test (for non-normally distributed data) for 2 group comparisons and Kruskal-Wallis for multiple group comparisons. P value, OR (≥12 to <12), and 95% CI for TMB >= 12 comparisons were determined using Fisher’s Exact.
**
The 180 UCSD patients with SCC and curated clinical data are a subset of the 9407 patients with SCC from the FM de-identified database.
Abbreviations: FM = Foundation Medicine: TMB = tumor mutational burden; UCSD = University of California San Diego