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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Vasc Surg. 2019 Feb 15;69(6):1924–1935. doi: 10.1016/j.jvs.2018.08.172

Figure 1. Large animal model of acute limb ischemia.

Figure 1.

Pigs underwent intravascular induction of acute limb ischemia (ALI) and placebo or SG-1002 (1600 mg PO) administration starting 7 days post-ALI and continued for 35 days. Weekly ABI measurements were performed and blood samples obtained. At day 42 follow-up arteriograms were acquired, animals euthanized and nonischemic and ischemic limb tissues collected (Figure 1A). Under fluoroscopic guidance, contrast arteriography was performed to evaluate baseline vessel architecture (Figure 1B). ALI was generated by deployment of an AMPLATZER™ Vascular Plug II inside a GORE® VIABAHN® Endoprosthesis into the external iliac artery followed by an arteriogram to verify occlusion (Figure 1C).