Figure 7. SG-1002 improves coronary vascular reactivity by an NO-dependent mechanism.

Left anterior descending (LAD) and left circumflex (LCX) coronary arteries were isolated from placebo and SG-1002 treated groups for isometric tension experiments. Coronary arteries were precontracted with PGF_2a and relaxation responses to endothelial-dependent bradykinin (Figure 7A and 7B) and substance P (Figure 7D and 7E). Endothelial-independent relaxation was determined by sodium nitroprusside (Figure 7G and 7H). Half maximal effective concentrations (EC₅₀) were calculated (Figure 7C, 7F and 7I). Values are means ± SEM with number of animals per group shown.