Skip to main content
. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Clin Cancer Res. 2019 Feb 12;25(11):3430–3442. doi: 10.1158/1078-0432.CCR-18-0440

Figure 1. Overexpressed nuclear AURKA is associated with a poor overall survival of HPV-negative HNSCC patients.

Figure 1

Nuclear expression of pAURKA/AURKA was assessed in 89 HNSCC surgical specimens using AQUA analysis. AURKA expression was classified into high or low AURKA expression based on relation to median AURKA levels. (A) Kaplan Meier curves were generated for all patients (n = 89) regarding AURKA level in nucleus regardless HPV positivity (HR 1.9, 95% CI 1.05–3.46). (B) Kaplan Meier curves were generated for 23 patients who got surgery only regarding pAURKA status after adjustment for T stage. (C) Representative AQUA images of pAURKA (top) and AURKA (bottom) in HNSCC surgical specimens. Scale bars: white: 100 µm, yellow: 10 µm. (D) Kaplan Meier curve for all patients (n = 89) who were grouped into 4 categories: p16-/Low AURKA; p16+/Low AURKA; p16−/High AURKA; p16+/High AURKA- classified by HPV positivity (p16) and AURKA status (HR 1.84, 95% CI 0.89–3.79).