Table 4.

Multiple linear regression analyses of medial frontal and insula ROI's age‐related change in D2–like receptor availability (BP_ND) using [¹⁸F]Fallypride PET

Model	Parameter	Medial orbital gyrus	Posterior orbital gyrus	Pre‐subgenual frontal cortex	Straight gyrus	Subcallosal area	Subgenual frontal cortex	Insula
	N	126	124	126	128	123	124	128
Baseline	R 2	0.283***	0.252***	0.184***	0.263***	0.039*	0.506***	0.043*
Linear	Age	−0.0057 [−0.009, −0.0024]	−0.0043 [−0.0078, −0.00086]	−0.0016 [−0.0039, 7e−04]	−0.007 [−0.011, −0.0032]	−0.031 [−0.071, 0.0087]	−0.0067 [−0.011, −0.0027]	−0.018 [−0.024, −0.012]
	R 2 change	0.063***	0.036*	0.012	0.072***	0.019	0.042**	0.214***
Quadratic	Age	−0.038 [−0.057, −0.019]	−0.028 [−0.048, −0.0072]	−0.016 [−0.029, −0.0023]	−0.041 [−0.062, −0.019]	−0.077 [−0.32, 0.17]	−0.029 [−0.053, −0.0057]	−0.065 [−0.099, −0.031]
	Age2	0.00034 [0.00014, 0.00054]	0.00024 [3.3e−05, 0.00046]	0.00015 [9.7e−06, 0.00029]	0.00035 [0.00013, 0.00058]	0.00049 [−0.002, 0.003]	0.00024 [−7e−06, 0.00048]	5e−04 [0.00015, 0.00085]
	R 2 change	0.057***	0.03*	0.028*	0.047**	0.001	0.013	0.044**

Notes. Significant effects are denoted in bold. Full regression tables can be found in the online application http://13.58.222.229:3838/agebp/.

*p < .05. **p < .01. ***p < .001.