Table 3.
Low-dose aspirin and risk differences (RD) relative to placebo per 100 couples attempting pregnancy for pregnancy, pregnancy loss and live birth by metabolic syndrome, metabolic syndrome score and metabolic syndrome components
| Pregnancy | Pregnancy lossa | Live birth | |||||||
|---|---|---|---|---|---|---|---|---|---|
| RD | 95% CI | p-intb | RD | 95% CI | p-intb | RD | 95% CI | p-intb | |
| Metabolic syndrome score | |||||||||
| 0 | 10.7 | (1.2, 20.2) | −6.6 | (−17.3, 4.1) | 13.7 | (3.3, 24.0) | |||
| 1 | 3.9 | (−5.7, 13.5) | 0.33 | 0.1 | (−10.8, 11.0) | 0.39 | 2.0 | (−8.6, 12.6) | 0.12 |
| 2 | −0.2 | (−13.0, 12.6) | 0.18 | −1.4 | (−16.1, 13.2) | 0.58 | −1.1 | (−15.7, 13.4) | 0.10 |
| 3+ | −3.6 | (−15.5, 8.4) | 0.07 | 2.2 | (−11.4, 15.9) | 0.32 | 0.3 | (−13.3, 13.9) | 0.13 |
| Metabolic syndrome | |||||||||
| No | 5.7 | (−0.2, 11.7) | −2.7 | (−9.4, 4.0) | 6.0 | (−0.6, 12.6) | |||
| Yes | −3.6 | (−15.6, 8.5) | 0.18 | 2.2 | (−11.5, 15.9) | 0.53 | 0.3 | (−13.3, 13.9) | 0.46 |
| Waist circumference | |||||||||
| <88 cm | 5.7 | (−1.0, 12.5) | −1.0 | (−8.6, 6.6) | 6.8 | (−0.6, 14.3) | |||
| ≥88 cm | −0.05 | (−8.7, 8.6) | 0.30 | −3.1 | (−13.1, 7.0) | 0.75 | 1.7 | (−8.1, 11.4) | 0.41 |
| High-density lipoprotein | |||||||||
| >50 mg/dL | 8.9 | (1.3, 16.6) | −5.3 | (−13.9, 3.2) | 11.1 | (2.7, 19.5) | |||
| ≤50 mg/dL | −0.2 | (−7.7, 7.3) | 0.10 | 1.7 | (−6.8, 10.3) | 0.25 | −0.5 | (−8.9, 7.9) | 0.06 |
| Triglycerides | |||||||||
| <150 mg/dL | 7.3 | (1.2, 13.4) | −3.6 | (−10.5, 3.3) | 7.1 | (0.4, 13.8) | |||
| ≥150 mg/dL | −6.9 | (−18.0, 4.2) | 0.028 | 4.7 | (−7.8, 17.2) | 0.25 | −2.5 | (−15.0, 10.0) | 0.19 |
| Blood pressure | |||||||||
| <130 mmHg systolic and <85 mmHg diastolic | 4.8 | (−0.9, 10.5) | −2.7 | (−9.2, 3.8) | 5.9 | (−0.5, 12.2) | |||
| ≥130 mmHg systolic or ≥85 mmHg diastolic | −0.03 | (−14.6, 14.6) | 0.55 | 4.4 | (−12.1, 20.9) | 0.43 | 0.8 | (−15.5, 17.0) | 0.57 |
| Glucose | |||||||||
| <100 mg/dL | 4.0 | (−1.6, 9.5) | −1.9 | (−8.2, 4.4) | 5.0 | (−1.1, 11.2) | |||
| ≥100 mg/dL | 8.5 | (−11.3, 28.3) | 0.67 | 0.4 | (−22.7, 23.5) | 0.85 | 8.7 | (−14.2, 31.7) | 0.76 |
Models for pregnancy loss weighted by the strata-specific inverse probability of pregnancy based on the effect modifier (metabolic syndrome, metabolic syndrome score or metabolic syndrome component), low-dose aspirin treatment assignment, BMI, c-reactive protein, race/ethnicity, partner status, cigarette smoking, time since last pregnancy loss and site.
P-value for the additive interaction of metabolic syndrome, metabolic syndrome score or metabolic syndrome component and low-dose aspirin.
BMI indicates body mass index, CI confidence interval.