Table 2.
Proportion of those in each cognitively defined subgroup with ≥ 1 APOE ϵ4 allele, by study and overall
| Study | No domain | Memory | Executive | Language | Visuospatial | Multiple domains | Overall | p-valuea |
|---|---|---|---|---|---|---|---|---|
| ACT (n = 711) | 134 (35%) | 51 (46%) | 11 (24%) | 14 (24%) | 27 (30%) | 6 (32%) | 243 (34%) | 0.022 |
| ADNI (n = 650) | 185 (66%) | 139 (73%) | 10 (63%) | 30 (58%) | 48 (57%) | 15 (54%) | 427 (66%) | 0.07 |
| MAP (n = 386) | 45 (34%) | 33 (44%) | 1 (33%) | 23 (27%) | 9 (26%) | 21 (39%) | 132 (34%) | 0.24 |
| ROS (n = 393) | 49 (35%) | 26 (48%) | – | 31 (28%) | 26 (41%) | 11 (46%) | 143 (36%) | 0.08 |
| PITT (n = 1561) | 283 (54%) | 411 (70%) | 15 (65%) | 72 (44%) | 97 (57%) | 39 (44%) | 917 (59%) | 5.1 × 10−11 |
| Overall (n = 3701) | 696 (48%) | 660 (65%) | 37 (42%) | 170 (36%) | 207 (47%) | 92 (43%) | 1861 (50%) | 1.5 × 10−27 |
ap values based on χ2(4) for ROS, otherwise χ2 (5)