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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Carcinog. 2019 Mar 3;58(7):1105–1117. doi: 10.1002/mc.22995

Fig. 1. Effect of GSE procyanidins on the formation of CSC enriched prostaspheres in LNCaP, C4–2B, 22Rv1, PC3, and DU145 PCa cells.

Fig. 1.

Effect of different concentrations of GSE procyanidins, given as (A) single treatment or (B) multiple treatments, on CSC (CD44+-α2β1high) enriched prostaspheres formation. Treatments were done either as single exposure (only once at the beginning of the spheroid formation assay) or multiple dosing regimens (exposure every 4th day after 1st day of treatment) spread over a course of 14 days. Representative photomicrographs (X400 magnification) of CSC enriched prostaspheres depict a decrease in their number and size by multiple treatments of GSE. In all bar graphs statistical differences are shown w.r.t. respective controls. $, P<0.05; *, P<0.001. C, control; GSE, grape seed extract.