Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Carcinog. 2019 Mar 3;58(7):1105–1117. doi: 10.1002/mc.22995

Fig. 2. Effect of B2G2 (an active constituent of GSE procyanidins) on the formation of CSC enriched prostaspheres in LNCaP, C4–2B, 22Rv1, PC3, and DU145 PCa cells.

Fig. 2.

Effect of different concentrations of B2G2 given as (A) single treatment or (B) multiple treatments on CSC enriched prostasphere formation. Treatments were done either as single exposure (only once at the beginning of the spheroid formation assay) or multiple dosing regimens (exposure every 4th day after 1st day of treatment) spread over a course of 14 days. Representative photomicrographs (X400 magnification) of CSC enriched prostaspheres depict a decrease in their number and size by single treatment of B2G2. In all bar graphs statistical differences are shown w.r.t. respective controls. $, P<0.05; *, P<0.001. C, control; B2G2, procyanidin B2 3,3″-di-O-gallate.