Table 2.
Logistic regression for prediction of pathology parameters compared to no breast cancer using inter-quartile odds ratios (significant differences in bold type)
| Tyrer-Cuzick | Density residual | SNP18 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | OR per IQR | 95% CI | LR | OR per IQR | 95% CI | LR | OR per IQR | 95% CI | LR | |
| No BC | 8867 | 1.00 | Ref | 1.00 | Ref | 1.00 | Ref | |||
| BC | 495 | 1.29 | (1.16–1.43) | 21.95 | 1.58 | (1.41–1.78) | 56.87 | 1.55 | (1.37–1.75) | 49.92 |
| Incident stage 2+ | 68 | 0.95 | (0.71–1.27) | 0.13 | 1.59 | (1.17–2.16) | 8.43 | 1.79 | (1.30–2.46) | 12.65 |
| All stage 2+ | 136 | 1.32 | (1.09–1.60) | 7.60 | 1.84 | (1.49–2.29) | 29.77 | 1.72 | (1.37–2.15) | 21.62 |
| Incident interval | 91 | 1.56 | (1.24–1.96) | 13.60 | 1.73 | (1.33–2.25) | 15.94 | 1.53 | (1.16–2.02) | 8.98 |
| Grade 1 | 94 | 1.06 | (0.83–1.35) | 0.19 | 1.55 | (1.20–2.02) | 10.52 | 1.21 | (0.92–1.58) | 1.78 |
| EGP | 78 | 0.95 | (0.72–1.25) | 0.14 | 1.67 | (1.26–2.22) | 11.97 | 1.36 | (1.00–1.83) | 3.94 |
| Grade 3 | 102 | 1.35 | (1.08–1.69) | 6.77 | 1.42 | (1.10–1.83) | 7.15 | 1.37 | (1.06–1.79) | 5.62 |
| DCIS | 90 | 1.27 | (1.00-1.62) | 3.69 | 1.59 | (1.22–2.08) | 11.34 | 1.49 | (1.13–1.96) | 7.77 |
| ER negative | 35 | 1.39 | (0.96–2.03) | 2.85 | 1.13 | (0.73–1.76) | 0.29 | 1.15 | (0.74–1.80) | 0.37 |
| ER positive | 358 | 1.26 | (1.12–1.43) | 13.49 | 1.63 | (1.42–1.87) | 47.48 | 1.62 | (1.41–1.87) | 44.77 |
| HER2+ | 34 | 1.42 | (0.97–2.08) | 3.12 | 1.96 | (1.28–2.99) | 9.19 | 1.25 | (0.79–1.96) | 0.91 |