Table 3.
Breast cancer pathology by combined TC/DR/SNP18 risk groups
| TC/MD/SNP18 10-year risk% | Low < 2% | Average 2–3.49% | Above average 3.5–4.9% | Moderate/high ≥ 5% | Total |
|---|---|---|---|---|---|
| Number of women | 3003 | 3038 | 1587 | 1734 | 9362 |
| Invasive BC | 67 | 110 | 98 | 124 | 399 |
| Total BC | 85 | 140 | 115 | 155 | 495 |
| Proportion with BC | 2.83% | 4.58% | 7.25% | 8.9% | 5.29% |
| Invasive grade 1 | 23 | 26 | 20 | 23 | 92 |
| % Gd1 of invasive in group | 34.33% | 23.64% | 20.41% | 18.55% | 23.06% |
| Adjusted Gd1 10-year incidence ratea | 0.38% | 0.53% | 0.73% | 1.14% | 0.65% |
| Invasive grade 2 | 23 | 57 | 46 | 73 | 199 |
| % Gd2 in group | 34.33% | 51.82% | 46.94% | 58.87% | 49.87% |
| Adjusted Gd2 10-year incidence ratea | 0.38% | 1.16% | 1.68% | 3.63% | 1.40% |
| Invasive grade 3 | 20 | 27 | 29 | 26 | 102 |
| %Gd3 in group | 29.85% | 24.54% | 29.59% | 20.97% | 25.56% |
| Adjusted Gd3 10-year ratea | 0.33% | 0.55% | 1.06% | 1.29% | 0.72% |
| Grade unknown | 1 | 0 | 3 | 2 | 6 |
| ER + invasive BC | 58 | 98 | 86 | 116 | 358 |
| ER− invasive BC | 9 | 9 | 10 | 7 | 35 |
| ER unknown | 1 | 3 | 0 | 1 | 5 |
| DCIS | 18 | 27 | 17 | 29 | 91 |
| %DCIS | 21.18% | 18.84% | 14.78% | 18.82% | 17.94% |
| Cancer type unknown | 0 | 3 | 0 | 2 | 5 |
| EGP | 20 | 23 | 14 | 16 | 73 |
| %EGP in group | 23.53% | 16.55% | 12.17% | 10.32% | 14.75% |
| Rate per 1000, invasive ER− per 10-years | 0.16% | 0.19% | 0.38% | 0.37% | 0.26% |
| 10-year rate, ER+ | 1.26% | 2.66% | 3.81% | 7.23% | 3.22% |
| 10-year rate, all BC | 1.42% | 2.85% | 4.19% | 7.6% | 3.48% |
9/24 (37.5%) of the invasive cancers in those at < 1.5% risk were grade 1 compared to 8/58 (13.8%) in those at 8%+ risk (p = 0.02). However 3/33 (9%) of total cancers in those at < 1.5% risk were invasive ER− compared to 4/82 (4.9%) for those at 8%+ risk
aIncidence rates are adjusted to actual incidence from time of saliva collection