Table 1.

Description of methods of included economic evaluations

Authors (country)		Gordon et al. [12] (Australia)	Gordon et al. [26] (Australia)	Haines et al. [13] (Australia)	May et al. [27] (The Netherlands)	Mewes et al. [29] (The Netherlands)	Perrier et al. [25] (France)	Van Waart et al. [28] (The Netherlands)
Year		2005	2017	2010	2017	2013	2016	2018
Study design		Model based economic evaluation Study design is observational for both DAART and STRETCH	RCT with economic evaluation	RCT with economic evaluation	RCT with economic evaluation	Model based economic evaluation Hypothetical cohort of 1000	RCT with economic evaluation	RCT with economic evaluation
Period of intervention		STRETCH—8 weeks, up to 12 months follow-up DART—6 weeks, up to 12 months follow-up	8 months, up to 12 months follow-up	6 months, up to 12 months follow-up	18 weeks, up to 9 months follow-up	12 weeks, up to 6 months follow-up	6 months	1–4 months, 6 months follow-up
Analytic horizon		12 months	12 months	6 months	9 months	5 years	6 months	Less than 12 months
Setting		Community	Hospital and community	Hospital and community	Outpatient clinics		Community	Community
Population		Women with breast cancer, aged 25–74	Women with breast cancer aged 20–69, resident in Brisbane area	Women with newly diagnosed breast cancer undergoing adjuvant therapy	Histological diagnosis of breast cancer < 6 weeks pre- recruitment; stage M0; scheduled for chemotherapy; Age 25–75 years; no cancer treatment in 5 years preceding recruitment	Female breast cancer patients; aged < 50 years, premenopausal, had undergone adjuvant chemotherapy and/or hormonal therapy, had experienced a treatment-induced menopause and who reported at least a minimal level of menopausal symptoms	Breast cancer patients receiving first-line adjuvant chemotherapy	Patients scheduled for adjuvant chemotherapy for breast cancer at one of the 12 participating hospitals in wider Amsterdam region of the Netherlands between 2010 and 2012
Sample size	Study Group	DAART n = 36 STRETCH n = 31	Treatment n = 134	Intervention n = 46	Intervention n = 87		Intervention (n = 41)	OnTrack (n = 76) OncoMove (n = 77)
	Control group	Usual care (n = 208)	Usual care n = 60	Control n = 43	Control n = 78		Control (n = 19)	Control (n = 77)
Age, mean (SD)		DAART 59 (10.7) STRETCH 54 (11.3) Usual care 55 (10.3)	52 (8)	Intervention 55.9 (10.5) Control 54.2 (11.5)	Intervention 50.0 (7.9) Control 49.4 (7.6)	Age < 50 years	18–75 years	OnTrack 49.9 (8.4) OncoMove 50.5 (10.1) Usual Care 51.6 (8.8)
Intervention		DAART—early home-based physiotherapy intervention. Main components: Recovery of shoulder range of movement (SROM), Education, Tailored exercise prescription for self-management STRETCH—a group-based exercise and psychosocial intervention. Main components: Recovery of SROM, Education, Discussion of psychosocial issues	8-month exercise programme for women after surgery for primary breast cancer. Intervention delivered through either face‐to‐face home delivery or by telephone over an 8‐month period starting 6 weeks after breast surgery. The intervention involved 16 scheduled sessions	Participants received a multimedia instructional package with equipment. A programme combining a range of exercise approaches, with balance and shoulder mobility components Included progression	Supervised 1-h aerobic and resistance exercise (twice per week for 18 weeks). The programmeme was individualised to the patient’s personal preferences and fitness level. The 1-h exercise classes included a warming up (5 min), aerobic and muscle strength training (50 min) and a cooling down (5 min). Recommended to be physically active for at least 30 min a day on at least three other days	Physical exercise intervention consisting of a 12-week home-based exercise programme, individually tailored during an intake session with a physiotherapist	6-month supervised physical activity programme of indoor and outdoor group sessions in addition to usual dietary advice	OnTrack: moderate-to-high intensity, combined resistance and aerobic exercise programme, supervised by specially trained physiotherapists. Twice a week, six large muscle groups are trained, followed by 30 min of aerobic exercises OncoMove: home-based, low-intensity, individualised, self-managed physical activity programme, with the addition of behavioural reinforcement. Specially trained nurses encourage participants at each chemotherapy cycle to engage in 30 min of physical activity per day, 5 days a week
Control		Usual care, a population-based sample, representative of women with breast cancer in the same geographic area	Usual care group received no regular or formal advice outside of routine health care contacts	Active (sham intervention) control of flexibility and relaxation activities Video and supporting material looked but actual exercises described differed. No progression	Usual care—maintain habitual physical activity pattern up to week 18. Thereafter, offered routine exercise programmes after cancer treatment	usual care, waiting list control	Dietary advice only	Varied according to hospital guidelines and preferences but did not involve routine exercise
Primary health outcome of the study		DAART study outcomes: shoulder ROM, arm circumference, function, pain, STRETCH: shoulder ROM	QoL—FACT-B + 4	HRQoL—EQ-5D, EORTC C30	Fatigue—MFI	Endocrine symptoms—FACT-ES	Adherence to the intervention	Cardiorespiratory fitness—endurance and heart rate at the end of an incremental bicycle ergometer test

DAART Domiciliary Allied Health and Acute Care Rehabilitation Team, EORTC C30 European Organisation for Research and Treatment of Cancer Core questionnaire, EQ-5D EuroQol 5 dimensions, FACT-B +4 Functional Assessment of Cancer Therapy-Breast, FACT-ES Functional Assessment of Cancer Therapy Questionnaire Endocrine Scale, MFI multidimensional fatigue inventory and fatigue quality list, NA not applicable, QoL quality of life, RCT randomised control trial, STRETCH Strength Through Recreation Exercise Togetherness Care Health, SROM shoulder range of movement