Table 5.
Loss of heterozygosity/microsatellite instability frequency (%) in studied chromosomal regions within individual pathological groups
| Pathological features | LOH/MSI frequency (%) in chromosomal region | |||||
|---|---|---|---|---|---|---|
| 1p31.2 | 3p21.3 | 3p24.2 | 9p21.3 | 11p15.5 | 16q22.1 | |
| Histopathological type | ||||||
| NG | 7 | 7 | 14 | 17 | 17 | 13 |
| FA | 20 | 11 | 40a | 25 | 20 | 20 |
| PTC | 11 | 16a | 0 | 0 | 6 | 7 |
| FTC | 29a | 33a | 0 | 25 | 25 | 0 |
| pTNM | ||||||
| T1a + T1b | 4 | 20a | 0 | 0 | 0 | 4 |
| T2–T3 | 44a | 14 | 0 | 18 | 33a | 9 |
| N0 + Nx | 7 | 18a | 0 | 8 | 6 | 4 |
| N1 | 38a | 20 | 0 | 0 | 25a | 13 |
| AJCC | ||||||
| I | 12 | 20a | 0 | 4 | 7 | 8 |
| II–IV | 22a | 14 | 0 | 11 | 18a | 0 |
| Td (mm) | ||||||
| < 10 | 6 | 20a | 0 | 11 | 0 | 0 |
| 10–30 | 25a | 15 | 0 | 6 | 11 | 11 |
| > 30 | 18 | 13 | 25 | 10 | 33a | 22 |
AJCC American Joint Committee on Cancer stage, FA follicular adenoma, FTC follicular thyroid carcinoma, LOH loss of heterozygosity, MSI microsatellite instability, N0/Nx no regional lymph node involvement, N1 regional lymph node involvement, NG nodular goiter, PTC papillary thyroid carcinoma, pTNM pathological tumor-node-metastasis, T1 tumor size pT1, T2–T3 tumor size pT2–T3, Td tumor diameter
aComparison between particular chromosomal regions within an individual pathological group P < 0.05