Fig. 4.

Forest plot for odds ratios (a) and focused principal component analysis (FPCA, b) for the association between sepsis mediators and intensive care unit mortality. b Correlation of ICU mortality (dependent variable at the center) with sepsis mediators at day 1, patient’s severity (as assessed by SAPS II score), organ dysfunction (as assessed by SOFA score at septic shock onset) and lactate clearance (relative difference between lactate concentration at septic shock onset and after 24 h of resuscitation) as a surrogate of early sepsis resolution. See Fig. 2 legend for details on FPCA. Variables positively and negatively correlated with ICU mortality are in green and yellow, respectively. See text for sepsis mediators’ abbreviations