. 2019 May 29;10:564. doi: 10.3389/fneur.2019.00564

Table 4.

Adjusted hazard ratio of BP levels for the incidence of the first-ever stroke by age, sex, and stroke types in this cohort study (95% CI).

Groups	Stroke		IS		ICH
	< 65 years	≥ 65 years	< 65 years	≥ 65 years	< 65 years	≥ 65 years
TOTAL
SBP, mmHg	1.016 (1.012, 1.021)^*	1.014 (1.008, 1.020)^*	1.015 (1.009, 1.021)^*	1.009 (0.999, 1.019)	1.023 (1.012, 1.034)^*	1.012 (0.996, 1.029)
< 130	1.00	1.00	1.00	1.00	1.00	1.00
130~	1.37 (1.09, 1.73)^*	1.16 (0.64, 2.11)	1.44 (1.10, 1.89)^*	0.80 (0.32, 1.99)	1.14 (0.68, 1.93)	0.86 (0.21, 3.50)
140~	2.33 (1.81, 3.01)^*	1.65 (0.98, 2.78)	2.44 (1.81, 3.28)^*	1.11 (0.52, 2.40)	2.17 (1.24, 3.80)^*	0.86 (0.24, 3.11)
160~	5.36 (3.75, 7.64)^*	2.19 (1.21, 3.97)^*	5.15 (2.34, 7.94)^*	1.62 (0.68, 3.87)	4.53 (1.98, 10.37)^*	2.82 (0.80, 9.88)
≥180	5.47 (3.52, 8.49)^*	3.35 (1.86, 6.06)^*	4.61 (2.62, 8.08)^*	1.51 (0.57, 3.97)	6.28 (2.54, 15.52)^*	1.72 (0.36, 8.20)
DBP, mmHg	1.029 (1.020, 1.037)^*	1.033 (1.021, 1.046)^*	1.026 (1.016, 1.037)^*	1.025 (1.005, 1.046)^*	1.040 (1.021, 1.059)^*	1.031 (1.000, 1.063)
< 80	1.00	1.00	1.00	1.00	1.00	1.00
80~	1.26 (1.00, 1.59)^*	1.43 (0.82, 2.50)	1.16 (0.88, 1.52)	0.73 (0.31, 1.72)	1.97 (1.15, 3.35)^*	0.56 (0.12, 2.57)
90~	2.15 (1.67, 2.78)^*	2.06 (1.22, 3.46)^*	2.20 (1.64, 2.96)^*	1.18 (0.55, 2.54)	2.09 (1.11, 3.91)^*	1.78 (0.55, 5.79)
100~	3.69 (2.54, 5.38)^*	2.65 (1.42, 4.65)^*	3.04 (1.90, 4.87)^*	2.19 (0.92, 5.20)	4.65 (2.00, 10.82)^*	2.22 (0.53, 9.36)
≥110	6.60 (4.20, 10.37)^*	4.70 (2.45, 9.00)^*	6.22 (3.60, 10.77)^*	2.33 (0.82, 6.63)	9.22 (3.58, 23.71)^*	3.61 (0.75, 17.46)
MEN
SBP, mmHg	1.035 (1.027, 1.042)^*	1.017 (1.008, 1.025)^*	1.034 (1.025, 1.043)^*	1.008 (0.994, 1.023)	1.034 (1.019, 1.049)^*	1.015 (0.995, 1.035)
< 130	1.00	1.00	1.00	1.00	1.00	1.00
130~	1.19 (0.89, 1.60)	1.00 (0.49, 2.02)	1.25 (0.88, 1.77)	0.37 (0.11, 1.26)	1.18 (0.64, 2.18)	1.04 (0.23, 4.74)
140~	1.69 (1.19, 2.37)^*	1.36 (0.73, 2.54)	1.97 (1.32, 2.95)^*	0.85 (0.35, 2.06)	1.32 (0.61, 2.86)	0.69 (0.15, 3.12)
160~	3.95 (2.36, 6.61)^*	2.06 (0.99, 4.30)	3.64 (1.90, 7.00)^*	0.95 (0.28, 3.18)	4.47 (1.57, 12.71)^*	3.08 (0.72, 13.21)
≥180	2.42 (1.23, 4.75)^*	3.11 (1.45, 3.08)^*	2.81 (1.25, 6.33)^*	1.19 (0.33, 4.26)	2.19 (0.48, 9.94)	2.12 (0.32, 13.99)
DBP, mmHg	1.052 (1.040, 1.063)^*	1.037 (1.020, 1.054)^*	1.052 (1.038, 1.065)^*	1.018 (0.990, 1.047)	1.054 (1.030, 1.078)^*	1.047 (1.009, 1.087)^*
< 80	1.00	1.00	1.00	1.00	1.00	1.00
80~	1.49 (1.09, 2.04)^*	1.50 (0.76, 2.95)	1.44 (0.98, 2.10)	0.65 (0.23, 1.80)	2.39 (1.19, 4.79)^*	0.56 (0.09, 3.37)
90~	2.76 (1.97, 3.88)^*	1.82 (0.96, 3.43)	3.01 (2.01, 4.49)^*	0.93 (0.38, 2.29)	2.46 (1.09, 5.55)^*	1.37 (0.34, 5.51)
100~	3.31 (1.86, 5.91)^*	2.38 (1.06, 5.34)^*	3.62 (1.83, 7.14)^*	1.68 (0.52, 5.39)	3.23 (0.81, 11.99)	3.61 (0.76, 17.10)
≥110	7.37 (3.83, 14.18)^*	5.32 (2.37, 11.93)^*	7.15 (3.17, 16.15)^*	1.54 (0.38, 6.26)	9.78 (2.65, 36.18)^*	6.74 (1.22, 37.09)^*
WOMEN
SBP, mmHg	1.025 (1.019, 1.032)^*	1.009 (1.001, 1.018)^*	1.023 (1.015, 1.031)^*	1.008 (0.995, 1.021)	1.029 (1.014, 1.043)^*	1.007 (0.980, 1.035)
< 130	1.00	1.00	1.00	1.00	1.00	1.00
130~	1.20 (0.81, 1.77)	1.70 (0.56, 5.19)	1.34 (0.87, 2.08)	3.47 (0.65, 18.66)	0.55 (0.16, 1.88)	—
140~	2.02 (1.36, 2.99)^*	1.96 (0.76, 5.07)	1.94 (1.21, 3.09)^*	1.77 (1.34, 9.28)^*	2.38 (1.02, 5.54)^*	1.15 (0.10, 13.85)
160~	3.81 (2.29, 6.31)^*	2.62 (0.96, 7.14)	3.98 (2.21, 7.18)^*	5.12 (1.05, 25.02)^*	2.00 (0.45, 8.85)	2.20 (0.19, 25.45)
≥180	5.18 (2.94, 9.13)^*	3.25 (1.24, 8.48)^*	4.19 (1.98, 8.90)^*	2.58 (0.46, 14.34)	5.95 (1.88, 18.88)^*	1.15 (2.07, 19.09)
DBP, mmHg	1.035 (1.023, 1.047)^*	1.027 (1.009, 1.045)^*	1.031 (1.016, 1.045)^*	1.033 (1.005, 1.061)^*	1.043 (1.014, 1.072)^*	0.997 (0.939, 1.058)
< 80	1.00	1.00	1.00	1.00	1.00	1.00
80~	1.02 (0.72, 1.45)	1.21 (0.45, 3.24)	0.94 (0.63, 1.41)	1.18 (0.25, 5.48)	1.19 (0.51, 2.82)	0.64 (0.04, 10.50)
90~	1.47 (0.99, 2.19)	2.43 (1.01, 5.83)^*	1.51 (0.96, 2.37)	1.93 (0.48, 7.78)	1.28 (0.46, 3.61)	2.20 (0.31, 25.67)
100~	3.81 (2.29, 6.31)^*	3.28 (1.23, 8.78)^*	2.78 (1.45, 5.30)^*	5.10 (1.22, 21.29)^*	4.28 (1.40, 13.11)^*	-
≥110	5.18 (2.94, 9.13)^*	3.17 (1.08, 9.29)^*	4.89 (2.34, 10.20)^*	3.47 (0.67, 18.02)	6.08 (1.71, 26.12)^*	-

indicated P < 0.05.