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. 2019 May 29;10:522. doi: 10.3389/fgene.2019.00522

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Copyright © 2019 Liu, Liu, Jin, Du, He and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of DNA methylation of cyp19a1a promoter on cAMP-stimulated activities. Unmethylated and methylated reporter plasmids were transfected to HEK 293T cells. Luciferase activities were measured 48 h after transfection. Fold change was calculated, and cyp19a1a-Luc group was used as control. (A) The CREB mediated stimulation of cyp19a1a promoter activities by forkolin in HEK 293T cells. (B) The location of CG sites and CREB sites in two approximate clusters of cyp19a1a promoter. The data was shown as mean ± SD (n = 3). ^∗∗P < 0.01 represented significantly different.