FIGURE 3.

Ablation of p75^NTR in Schwann cells has no impact on re-myelination after nerve injury. (A) Representative light microscopy images of toluidine-blue stained semithin transverse sections of sham contralateral and distal stumps from crush injured nerves, 15- and 29-days post-lesion. Scale bar 20 μm. (B–G) Histograms obtained from the morphometrical analysis of the myelinated fibers. (B) Total number of myelinated fibers, (C) axon diameter, (D) fiber diameter, (E) myelin thickness, and (F) g-ratio. Scatter plots showing g-ratio of individual myelinated axons as a function of axon diameter in contralateral shams (G) or injured nerves at time points of 15 (H) and 29 days post lesion (I). Numbers for quantifications were as follows: n = 11 sham, n = 6 at 15 days, and n = 6 at 29 days for SC-p75^NTR-KO; n = 9 sham, n = 3 at 15 days, and n = 6 at 29 days for littermates.