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. 2019 May 29;10:1132. doi: 10.3389/fmicb.2019.01132

FIGURE 2.

FIGURE 2

Simplified schematic overview of the proposed DMS degradation and subsequent route of sulfur oxidation in Methylophaga thiooxydans DMS010. Boden et al. (2010) suggested that DMS is initially degraded by a suggested cobalamin-dependent and as yet unidentified methyltransferase in the cytoplasm. Methanethiol (MT) would need to transfer to the periplasm where the methanethiol oxidase (Mto) degrades MT further as described in the text. The suggested steps of the sulfur oxidation pathway according to enzyme essays, proteomics and transcriptomics analyses are indicated. MT, methanethiol; X?, unidentified putative methyltransferase; H4F, tetrahydrofolate; CM, cytoplasmic membrane; OM, outer membrane; Mto, methanethiol oxidase; SuDH, sulfide dehydrogenase (flavocytochrome); SQRp, periplasmatic sulfide:quinone reductase; SQRc, cytoplasmatic sulfide:quinone reductase; Q, quinone, QH2, quinol; SulP, sulfate permease; TauE, sulfite exporter; PDO, persulfide dioxygenase; TSDH, thiosulfate dehydrogenase; C550, cytochrome 550 (located in the cytoplasmic membrane).