Table 1.

Summary of drug inhibitors, their target pathway and their effect on MHC-I downregulation.

Inhibitor	Concentration	Pathway targeted	MHC-I recovery during IAV infection	MHC-I recovery during IBV infection
Dynasore	50 μM	Dynamin-dependent endocytosis	−	+++
Genistein	25 μg/ml	Clathrin-independent endocytosis	–	+
Chlorpromazine (CPZ)	10 μg/ml	Clathrin-dependent endocytosis	–	+
NH4Cl	10 μM	Lysosome-mediated degradation	–	–
MG132	5 μM	Proteosome-mediated degradation	+++	++