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. 2019 May 29;9:180. doi: 10.3389/fcimb.2019.00180

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Copyright © 2019 Probst, Nguyen, El-Sakkary, Skinner, Suzuki, Buckner, Gelb, Caffrey and Debnath.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration-dependent inhibition of growth of E. histolytica by tipifarnib, lonafarnib, and simvastatin, as compared to metronidazole. Different concentrations of compounds were tested in triplicate for activity against E. histolytica trophozoites. The data points represent mean percentage growth inhibition and standard error of mean (SEM) of different concentrations of metronidazole, tipifarnib, lonafarnib and simvastatin. EC₅₀ curves were generated from mean values of percentage growth inhibition ± SEM of metronidazole, tipifarnib, lonafarnib, and simvastatin against E. histolytica.