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. 2019 May 29;9:180. doi: 10.3389/fcimb.2019.00180

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Copyright © 2019 Probst, Nguyen, El-Sakkary, Skinner, Suzuki, Buckner, Gelb, Caffrey and Debnath.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotypic changes in E. histolytica upon administration of FTI lonafarnib in combination with metronidazole. E. histolytica trophozoites were photographed 24 h after treatment with lonafarnib and metronidazole using a Zeiss Axiovert A1 inverted microscope and a Zeiss AxioCam 503 mono digital camera controlled by Zen 2 lite software. The trophozoites were treated with 7.4 μM of lonafarnib alone (A), 1.9 μM of metronidazole alone (B), a combination of 7.4 μM of lonafarnib and 1.9 μM of metronidazole (C), 0.5% DMSO (D) and 50 μM of metronidazole (E). White arrow indicates normal morphology of trophozoites and black arrow indicates rounded, lysed trophozoites. Trophozoites were photographed at 20 × magnification.