Table 7.
First pass screening of FTIs at 10 μM against S. mansoni somules and adults.
| Compound | Somule severity score at 48 h | Adult severity score at 48 h |
|---|---|---|
| Lonafarnib* | 4 | 4 |
| Tipifarnib* | 4 | 4 |
| CHN-13* | 4 | 4 |
| CHN-15 | 4 | 4 |
| HB-19 | 4 | 4 |
| HB-20 | 4 | 4 |
| HB-23 | 4 | 4 |
| HB-26 | 4 | 4 |
| JK-02* | 4 | 1 |
| JK-17* | 4 | 2 |
| JK-19* | 4 | 4 |
| JK-24 | 4 | 4 |
| JK-25 | 4 | 4 |
| JK-31 | 4 | 4 |
| JK-35 | 4 | 4 |
| PN-149 | 4 | 3 |
| PN-077 | 4 | 4 |
Screens were performed twice each in duplicate and representative data are shown. Compounds with asterisks were also those most potent against E. histolytica in first pass screens (Table 1).