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. 2019 Jun 4;14:193. doi: 10.1186/s11671-019-2985-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Anticancer effects and safety of DMP/siRNA on C26 mouse xenograft model. a Tumor development curve, calculated by tumor volume. b Average weight of tumors in each group. Compared with other treatment groups, the DMP/siMcl1 group and DMP/ siBcl-xl group achieved a statistically significant reduction in tumor weight (***P, 0.001). c Representative images of tumors of C26 colon carcinoma. d Apoptosis in tumor tissues detected by TUNEL assay. e HE analysis of main organs from each treatment group in both models. No significantly pathological changes were observed in heart, liver, spleen, lung, or kidney