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. 2019 May 29;10:593. doi: 10.3389/fphar.2019.00593

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Copyright © 2019 Tsoi, Chen, Gao, Wang, Yuen, Yang and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AGNHW ameliorated middle cerebral artery occlusion (MCAO)-induced neurological deficits, decreased infarct size, and preserved blood–brain barrier (BBB) integrity. Male Sprague–Dawley (SD) rats were subjected to 2 h of ischemia and 22 h of reperfusion to establish the MCAO model. AGNHW (257 mg/kg, suspended in saline) was given to animals before reperfusion. (A) Modified Neurological Severity Score (mNSS) was evaluated 24 h after the onset of ischemia–reperfusion based on an 18-point scale (n = 12). (B) Infarct size measured by TTC staining 24 h after the onset of ischemia–reperfusion (n = 10). (C) Evans blue content measured 24 h after the onset of ischemia–reperfusion (n = 10). All data are means ± S.E.M. The significance of differences was from Sham at ***p < 0.001 and from MCAO at ^### p < 0.001.