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. 2019 May 29;10:593. doi: 10.3389/fphar.2019.00593

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Copyright © 2019 Tsoi, Chen, Gao, Wang, Yuen, Yang and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AGNHW did not influence liver and kidney functions in normal rats. AGNHW was given to normal rats at three concentrations (257, 514, and 1,028 mg/kg) for seven consecutive days. Blood samples were collected on day 2, day 8, and day 14 after the first administration. Organ samples were collected on day 14 after the first administration. (A) Body weight changes. (B) Organ index. (C) ALT and (D) AST activity in the plasma. (E) Creatinine and (F) BUN level in the plasma. (G) Histological examination on liver and kidney morphology. Scale bar = 100 μm.