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. 2019 Apr 6;6(11):1900023. doi: 10.1002/advs.201900023

Figure 3.

Figure 3

Cellular internalization of polycation/miRNA complexes in CMs or heart. A) Cellular internalization assay by MD where PEI/miR‐Cy3 was performed at the N/P ratio of 10. B) Confocal fluorescence images of H9C2 cells treated with miR‐Cy3 or polycation/miR‐Cy3(red) at the N/P ratio of 10 (scale bar: 50 µm). C) Image and relative radiant efficiency of mice hearts treated with saline, free miR‐Cy3, PEI/miR‐Cy3 or CHO‐PGEA/miR‐Cy3. D) Fluorescence images of heart section in four groups (scale bar: 100 μm). *P < 0.05, **P < 0.01, and ***P < 0.001; Data are from 3 independent experiments.