TABLE 3.
Statistical summary of treatment comparisons
| Variable | Analyte | Comparison (Treatment C vs. Reference) | Geometric Mean Ratio (Treatment C/Reference) | 90% CI |
|---|---|---|---|---|
| Cmax (ng/ml) | Naloxone | C vs. B | 81.5 | 63.6–105 |
| Naltrexone | C vs. A | 38.4 | 25.7–57.3 | |
| 6β-Naltrexol | C vs. A | 101 | 92.7–110 | |
| AUC0–inf (ng·h/ml) | Naloxone | C vs. B | 84.6 | 70.3–102 |
| Naltrexone | C vs. A | 61.6 | 50.9–74.6 | |
| 6β-Naltrexol | C vs. A | 94.4 | 89.3–99.8 |
AUC0–inf, area under the plasma concentration-time curve from time zero to infinity; CI, confidence interval; Treatment A, 2 mg naltrexone, intranasally; Treatment B, 4 mg naloxone, intranasally; Treatment C, 2 mg naltrexone plus 4 mg naloxone, intranasally.