TABLE 5.

Impact of AZD3965 on GHB brain-to-plasma partitioning with oral GHB administration

Data are presented as mean (S.D.). n = 4. ***P < 0.01 determined by Student’s t test.

Time of Sacrifice after GHB Administration	Brain-to-Plasma Ratio
	Oral GHB (14.4 mmol/kg)	Oral GHB (14.4 mmol/kg) + AZD3965 (5 mg/kg) 60 min PD
min
65	0.365 (0.0627)	0.334 (0.365)
120	0.392 (0.0551)	0.0789 (0.0104)***

PD, postdose.