Table 1.
Parameters, their values, and references
| Parameter name | Parameter value | Parameter description | Method of obtention |
|---|---|---|---|
| ncopy for 257 | 20 | Copy number for the 257 construct | Novagen (Supplier) |
| ncopy for 157 | 10 | Copy number for the 157 construct | Novagen (Supplier) |
| ncopy for 357 | 40 | Copy number for the 357 construct | Novagen (Supplier) |
| ncopy for 457 | 100 | Copy number for the 457 construct | Novagen (Supplier) |
| n | 1.84728055622324 ± 0.167856095615895 (dimensionless) | Cooperativity constant of the Hill model | Fitted on pinocembrin data |
| Ratio for 157 | 0.142356903084492 ± 0.0145559485207119 (AU) | Dynamic range of the construct divided by its copy number | Fitted on pinocembrin data |
| Ratio for 257 | 0.707131941851998 ± 0.0352622736990071 (AU) | Dynamic range of the construct divided by its copy number | Fitted on pinocembrin data |
| Ratio for 357 | 1.76685307850461 ± 0.0224367736516089 (AU) | Dynamic range of the construct divided by its copy number | Fitted on pinocembrin data |
| Ratio for 457 | 0.417451006235614 ± 0.0108399220317623 (AU) | Dynamic range of the construct divided by its copy number | Fitted on pinocembrin data |
| Correcting factor for naringenin | 1.3 | Correcting fold change factor | Estimated by averaging the correcting factors for individual constructs |
| Kdsingle | 887.835649014124 ± 120.681558027955 (µM) | The Hill constant, K d, for a single plasmid | Fitted on pinocembrin data |
| Km for pinocembrin | 1 (dimensionless) | Ratio between the binding constants of the inducer and the transcription factor | By definition |
| Km for naringenin | 2.14168405285072 ± 0.206020050654161 (dimensionless) | Ratio between the binding constants of the inducer and the transcription factor | Fitted on naringenin data |
| n_tf | 2 (dimensionless) | The transcription factor forms dimers | Naringenin dose–response reference |