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. 2019 May 29;10:595. doi: 10.3389/fphar.2019.00595

Figure 4.

Figure 4

Seizure activity following an intraperitoneal injection of 0.3 mg/kg CUMYL-4CN-BINACA (4CN), pre-treated with vehicle, SR141716 (3 or 30 mg/kg), or AM-630 (3 mg/kg). Data are presented as (A) total Racine scores computed from weighted sums of each seizure behavior, which are presented individually in Table 2 . Generalized tonic-clonic seizures were quantified but not observed under any condition. Locomotor data are presented in panel (B). Bars represent mean ± SEM, with n = 5–6 per group; **p < .01, one-way ANOVA with Dunnett’s contrasts, comparing each condition to the vehicle + 0.3 mg/kg CUMYL-4CN-BINACA condition.