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. 2019 May 29;10:623. doi: 10.3389/fphar.2019.00623

Figure 5.

Figure 5

Protein expression of total STAT3, p-tyr-705 STAT3, C/EBPβ and COX-2 following treatment with AG490 (JAK2 inhibitor). Cell culture conditions are as described in Figure 4 . Tumor cells (HepG2 and SMMC-7721) were divided into different groups and treated with different concentrations of AG490 as follows: 1) control group: cells received no drug treatment; 2) cells treated with IL-6 (25 ng/ml) only; 3) cells treated with IL-6 (25 ng/ml) + AG490 (10 µmol/L); 4) cells treated with IL-6 (25 ng/ml) + AG490 (50 µmol/L); 5) cells treated with IL-6 (25 ng/ml) + AG490 (100 µmol/L).