Table 3. The genotype and allele frequencies comparison of FGFR2 polymorphisms between the case and control groups.
| Genotype/allele | Case, n=145 (%) | Control, n=123 (%) | OR (95% CI) | P-value | ORa (95% CI) | P-valuea | PHWE | |
|---|---|---|---|---|---|---|---|---|
| rs2981582 | CC | 51 (35.17) | 58 (47.15) | Ref. | - | 0.983 | ||
| CT | 68 (46.90) | 53 (43.09) | 1.459 (0.867–2.455) | 0.154 | 1.345 (0.790–2.288) | 0.275 | ||
| TT | 26 (17.93) | 12 (9.76) | 2.464 (1.129–5.379) | 0.021 | 2.085 (0.936–4.644) | 0.072 | ||
| TT vs CC+CT | 119 (82.07) | 111 (90.24) | 2.021 (0.973–4.199) | 0.056 | 1.780 (0.841–3.767) | 0.131 | ||
| TT+CT vs CC | 94 (64.83) | 65 (52.85) | 1.645 (1.006–2.688) | 0.047 | 1.482 (0.895–2.453) | 0.126 | ||
| C | 170 (58.62) | 169 (68.70) | Ref. | - | ||||
| T | 120 (41.38) | 77 (31.30) | 1.549 (1.084–2.213) | 0.016 | 1.419 (0.984–2.045) | 0.061 | ||
| rs2420946 | GG | 36 (24.83) | 45 (36.59) | Ref. | - | 0.609 | ||
| AG | 78 (53.79) | 61 (49.59) | 1.598 (0.921–2.775) | 0.095 | 1.664 (0.944–2.934) | 0.078 | ||
| AA | 31 (21.38) | 17 (13.82) | 2.279 (1.092–4.759) | 0.027 | 2.238 (1.055–4.746) | 0.036 | ||
| AA vs GG+AG | 114 (78.62) | 106 (86.18) | 1.696 (0.887–3.241) | 0.108 | 1.635 (0.841–3.179) | 0.147 | ||
| AA+AG vs. GG | 109 (75.17) | 78 (63.41) | 1.747 (1.032–2.956) | 0.037 | 1.796 (1.048–3.079) | 0.033 | ||
| G | 150 (51.72) | 151 (61.38) | Ref. | - | ||||
| A | 140 (48.28) | 95 (38.62) | 1.484 (1.051–2.094) | 0.025 | 1.482 (1.042–2.109) | 0.029 | ||
| rs1219648 | TT | 32 (22.07) | 42 (34.15) | Ref. | - | 0.238 | ||
| CT | 79 (54.48) | 65 (52.84) | 1.595 (0.907–2.807) | 0.104 | 1.619 (0.905–2.897) | 0.105 | ||
| CC | 34 (23.45) | 16 (13.01) | 2.789 (1.316–5.916) | 0.007 | 2.900 (1.341–6.271) | 0.007 | ||
| CC vs TT+CT | 111 (70.35) | 107 (86.99) | 2.048 (1.068–3.927) | 0.029 | 2.106 (1.082–4.099) | 0.028 | ||
| CC+CT vs. TT | 113 (77.93) | 81 (65.85) | 1.831 (1.066–3.146) | 0.028 | 1.870 (1.070–3.265) | 0.028 | ||
| T | 143 (49.31) | 149 (60.57) | Ref. | - | ||||
| C | 147 (50.69) | 97 (39.43) | 1.579 (1.119–2.228) | 0.009 | 1.602 (1.126–2.279) | 0.009 | ||
| rs2981579 | CC | 27 (18.62) | 35 (28.46) | Ref. | - | 0.965 | ||
| CT | 80 (55.17) | 61 (49.59) | 1.700 (0.931–3.106) | 0.083 | 1.807 (0.875–3.730) | 0.110 | ||
| TT | 38 (26.21) | 27 (21.95) | 1.824 (0.903–3.688) | 0.093 | 1.638 (0.880–3.050) | 0.120 | ||
| TT vs CC+CT | 107 (73.79) | 96 (78.05) | 1.263 (0.718–2.222) | 0.418 | 1.282 (0.717–2.292) | 0.401 | ||
| TT+CT vs CC | 118 (81.83) | 88 (71.54) | 1.738 (0.980-3.083) | 0.057 | 1.690 (0.936–3.051) | 0.082 | ||
| C | 134 (46.21) | 131 (53.25) | Ref. | - | ||||
| T | 156 (53.79) | 115 (46.75) | 1.326 (0.943–1.864) | 0.104 | 1.317 (0.929–1.867) | 0.123 | ||
Note: a: OR and P value was adjusted by clinical parameters; HWE: Hardy-Weinberg equilibrium