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. 2019 Jun 4;39(6):BSR20182366. doi: 10.1042/BSR20182366

Figure 7. Inactivation of Wnt/β-catenin signaling pathway inhibits proliferation and invasion of HOS and U2OS cells.

Figure 7

(A) Proliferation of HOS and U2OS cells after transfection with miR-27a mimic and with both miR-27a mimic and Dickkopf-1 examined by MTT assay. (B) Invasion of HOS and U2OS cells after transfection with miR-27a mimic and with both miR-27a mimic and Dickkopf-1 examined by Transwell assay (×200). (C) The protein bands of VEGF, c-Myc, cyclin D1 and GAPDH in HOS and U2OS cells after transfection with miR-27a mimic and with both miR-27a mimic and Dickkopf-1 examined by Western blot analysis. The measurement data were expressed as mean ± S.D. The comparison between two groups was analyzed by t test; the experiment was repeated three times; *P<0.05 compared with the miR-27a mimic group. Abbreviation: GAPDH, glyceraldehyde-3-phosphate dehydrogenase.