Table II.
Curcumin modulates miRNAs in colorectal cancer.
| Author, year | Cell line | miRNA | Downstream target(s) | (Refs.) |
|---|---|---|---|---|
| Toden et al, 2015; | HCT116, | miR-200b (↑) | EZH2 | (54,55) |
| Goel, 2017 | HCT116-5FUR | miR-200c (↑) | BMI1 | |
| miR-141 (↑) | SUZ12 | |||
| miR-429 (↑) | Ring1B | |||
| miR-101 (↑) | ||||
| Mudduluru et al, 2011; | Rko, HCT116 | miR-21 (↓) | Pdcd4 | (56,57) |
| Riaz Rajoka et al, 2018 | ||||
| Toden et al, 2015 | HCT116, | miR-34a (↑) | FBXW7 | (58) |
| SW480 | miR-27a (↓) | CDK4, 6 | ||
| Cyclin D, E | ||||
| c-Myc | ||||
| Li et al, 2018 | HCT116 | miR-491 (↑) | PEG10 | (59) |
| Gandhy et al, 2012 | RKO, SW480 | miR-27a (↓) | Sp1 | (60) |
| miR-20a (↓) | Sp3 | |||
| miR-17-5p (↓) | Sp4 | |||
| Dou et al, 2017 | SW480 | miR-130a (↓) | Wnt/β-catenin | (61) |
The upwards and downwards pointing arrows indicate up- and downegulation, respectively. EZH2, enhancer of zeste homolog 2; FBWX7, F-box and WD repeat domain containing 7; Pdcd4, programmed cell death 4; CDK, cyclin-dependent kinase.