Table IV.
Curcumin modulates miRNAs in breast cancer.
| Author, year | Cell line | miRNA | Downstream target(s) | (Refs.) |
|---|---|---|---|---|
| Wang et al, 2017 | MCF-7 | miR-21 (↓) | PTEN/Akt | (71) |
| Li et al, 2014 | MCF-7 | miR-19a (↓) | PTEN/Akt/p53 | (72) |
| miR-19b (↓) | ||||
| Yang et al, 2010; | MCF-7 | miR-15a (↑) | Bcl-2 | (73,74) |
| Norouzi et al, 2018 | miR-16 (↑) | |||
| Guo et al, 2013 | MDA-MB-231 | miR-34a (↑) | Bcl-2 | (75) |
| MDA-MB-435 | Bmi-1 | |||
| Kronski et al, 2014 | MDA-MB-231 | miR-181b (↑) | CXCL1 | (76) |
| CXCL2 |
The upwards and downwards pointing arrows indicate up- and downegulation, respectively. PTEN, phosphatase and tensin homolog; CXCL1/2, chemokine (C-X-C motif) ligand 1/2.