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. 2019 May 8;42(1):35–42. doi: 10.3892/or.2019.7152

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Copyright: © Nieddu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Combination of TRAIL-MSCs with BTZ causes synergistic cell death of classic and patient-derived neuroblastoma cell lines. (A) MSCs infected with a TRAIL lentivirus, or parental cells, were subjected to flow cytometric analysis with a TRAIL antibody. Cell death assays; (B) classic or (C) patient-derived neuroblastoma cell lines were cultured in the presence or absence of recombinant TRAIL (r-TRAIL), BTZ, mesenchymal stem cells engineered to express secreted TRAIL (TRAIL-MSCs) or their combinations. Error bars indicate the standard errors of the means of three (Kelly and SKNAS) or two (primary cell lines) experiments. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. MSCs, mesenchymal stem cells; TRAIL, tumour necrosis factor-related apoptosis-inducing ligand; BTZ, Bortezomib.