Table I.
Primary cell lines and patient information (Great Ormond Street Hospital cohort).
| Pathology number | A5 | 2820 | 1043008 | 0396 |
|---|---|---|---|---|
| Procedure | Diagnostic biopsy | Diagnostic biopsy | Biopsy, second relapse | Diagnostic biopsy |
| Diagnosis | Poorly differentiated neuroblastoma | Poorly differentiated neuroblastoma | Poorly differentiated neuroblastoma | Poorly differentiated neuroblastoma |
| Site of origin | ‘Right neck mass’ (mediastinal into right supraclavicular fossa) | Abdominal mass | Supraclavicular lymph node | Right inguinal lymph node |
| MYCN status | Not amplified | Not amplified | Diagnostic biopsy: not amplified | Not amplified |
| Chromosomal abnormalities | 1p loss, 11q and 17q status inconclusive | 1p loss, 11q loss, 17 gain | Diagnostic biopsy: 1p loss, 11q loss, 17q gain | 11q loss, 17q gain, no 1p/1q imbalance |
| Histopathology immunostaining | CD56+, NB84+ | CD56+, NB84+ | Diagnostic biopsy: CD56+, NB84+ | CD56+, NB84+ |