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. 2019 Jun 5;4:13. doi: 10.1038/s41536-019-0075-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — TMT promoted neurite extensions from grafted cells. a Representative images of GFP⁺ neurites at the ipsilateral striatum, ipsilateral internal capsule, ipsilateral cerebral peduncle, and spinal cord. Scale bars, 100 µm. In the TMT (−) group, extending GFP⁺ neuronal fibers were found in the ipsilateral striatum and ipsilateral internal capsule, but not in the ipsilateral cerebral peduncle or spinal cord. In the TMT (+) group, extending GFP⁺ neuronal fibers were found in the ipsilateral striatum, ipsilateral internal capsule, ipsilateral cerebral peduncle, and spinal cord. b Quantitative analysis of the number of GFP⁺ neurites at the ipsilateral internal capsule. The number of neurites was not significantly different between the TMT (−) group and the TMT (+) group. Mann–Whitney tests were performed; n = 4 in the TMT (−) group and n = 8 in the TMT (+) group. Data are presented as means ± SEM. c Quantitative analysis of the horizontal maximum distance of neuronal growth from the graft. The distance is significantly longer in the TMT (+) group than the TMT (−) group. Mann–Whitney tests were performed; p = 0.0219, n = 11 in the TMT (−) group and n = 10 in the TMT (+) group. Data are presented as means ± SEM. d Representative images of Fast blue⁺, GFP⁺ and CTIP2⁺ cells in the graft. In the TMT (+) group, double-labeled staining in the graft demonstrated that Fast blue⁺/GFP⁺ cells co-expressed CTIP2. Scale bar, 20 µm. e Representative images of GFP⁺ neurites and Synaptophysin⁺ vesicles on neuronal fibers around the ipsilateral red nucleus (arrows). Scale bars, 10 µm. Nuclear counter staining, 4,6-dimamidino-2-phenylindole (DAPI)