Table 1.
Baseline characteristics of the patients.
| Unweighted population | Weighted population* | |||||
|---|---|---|---|---|---|---|
| Surgery alone N = 122 | Adjuvant chemotherapy N = 159 | Standardized differences (%) | Surgery alone | Adjuvant chemotherapy | Standardized differences (%) | |
| Age, yr | 66.3 | 61.2 | −53.1 | 62.6 | 62.5 | −0.6 |
| Gender | 16.7 | −8.1 | ||||
| Male | 102 (83.6) | 142 (89.3) | 67.4 (85.3) | 126.0 (88.1) | ||
| Female | 20 (16.4) | 17 (10.7) | 11.6 (14.7) | 17.0 (11.9) | ||
| Charlson comorbidity index | −37.5 | 7.9 | ||||
| 0 or 1 | 95 (77.9) | 145 (91.2) | 68.0 (86.1) | 126.8 (88.7) | ||
| ≥2 | 27 (22.1) | 14 (8.8) | 11.0 (13.9) | 16.2 (11.3) | ||
| Neoadjuvant chemotherapy | 32 (26.2) | 18 (11.3) | −38.9 | 12.5 (15.8) | 22.6 (15.8) | −1.9 |
| Pathologic T | −6.2 | 3.9 | ||||
| ≤T2 | 13 (10.7) | 14 (8.8) | 8.9 (11.3) | 14.4 (10.1) | ||
| T3–4 | 109 (89.3) | 145 (91.2) | 70.1 (88.7) | 128.6 (89.9) | ||
| Pathologic N | 5.2 | 5.3 | ||||
| N1 | 36 (29.5) | 44 (27.7) | 22.9 (29.0) | 42.5 (29.7) | ||
| N2 | 50 (41.0) | 69 (43.4) | 29.8 (37.7) | 56.4 (39.4) | ||
| N3 | 36 (29.5) | 46 (28.9) | 26.3 (33.3) | 44.1 (30.9) | ||
| Total LN removed | 24.4 | 27.0 | 15.9 | 25.3 | 24.1 | −7.9 |
| Positive LN | 4.6 | 6.4 | 22.8 | 5.4 | 4.8 | −9.9 |
| CIS | 55 (45.1) | 50 (31.4) | −28.3 | 29.2 (37.0) | 49.3 (34.5) | −5.2 |
| LVI | 91 (74.6) | 127 (79.9) | 62.5 (79.1) | 113.4 (79.3) | 0.6 | |
| Positive margin | 10 (8.2) | 16 (10.1) | 6.5 | 5.5 (7.0) | 12.0 (8.4) | −5.1 |
| Histology | 17.9 | 4.3 | ||||
| Pure UC | 79 (64.8) | 114 (71.7) | 56.7 (71.8) | 103.8 (72.6) | ||
| Variant UC histology | 43 (35.2) | 45 (28.3) | 22.3 (28.2) | 39.2 (27.4) | ||
| Type of event | ||||||
| Metastasis | 69 (56.6) | 99 (62.3) | ||||
| Cancer-specific death | 74 (60.7) | 94 (59.1) | ||||
| Overall death | 98 (80.3) | 114 (71.7) | ||||
LN, lymph node; CIS, carcinoma in situ; LVI, lymphovascular invasion; UC, urothelial carcinoma.
Results are reported as n (%) unless otherwise indicated.
*To avoid immortal-time bias, the landmark analysis method was used with 4 months after surgery as the fixed time.