Table 2.
Multivariable analysis for evaluating the risk of overall mortality.
| Univariate | Multivariate* | ||||||
|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | ||
| Adjuvant chemotherapy | 0.545 | 0.411–0.722 | <0.0001 | 0.478 | 0.344–0.665 | <0.0001 | |
| Age | 1.028 | 1.013–1.044 | 0.0002 | 1.016 | 1.001–1.032 | 0.0412 | |
| Pathologic T | |||||||
| ≤T2 | 1 [Reference] | 1 [Reference] | |||||
| T3–4 | 2.197 | 1.276–3.782 | 0.0045 | 2.355 | 1.377–4.026 | 0.0018 | |
| Pathologic N | |||||||
| N1 | 1 [Reference] | 1 [Reference] | |||||
| N2 | 1.602 | 1.144–2.242 | 0.006 | 1.474 | 1.001–2.171 | 0.0496 | |
| N3 | 1.645 | 1.142–2.370 | 0.0075 | 1.129 | 0.729–1.749 | 0.5861 | |
| Positive lymph nodes | 1.014 | 1.001–1.027 | 0.0378 | 0.987 | 0.969–1.006 | 0.178 | |
| Lymph node density | 1.015 | 1.009–1.022 | <0.0001 | 1.018 | 1.010–1.026 | <0.0001 | |
| Neoadjuvant chemotherapy | 1.521 | 1.071–2.160 | 0.0192 | 1.38 | 0.927–2.056 | 0.113 | |
| Charlson comorbidity index | |||||||
| 0 or 1 | 1 [Reference] | 1 [Reference] | |||||
| ≥2 | 1.386 | 0.944–2.034 | 0.0956 | 0.996 | 0.637 | 1.557 | 0.9862 |
Time-varying covariate cox model with robust standard error. *Adjusted by covariates with p < 0.2 in the univariate analysis.